Henry Huggins picks up a stray dog, names him Ribsy and sets out on numerous adventures with him, including breeding hundreds of fish and collecting over a thousand worms.

When her father loses his job, seven-year-old Ramona Quimby thinks of ways to deal with the many problems that develop.

Separated from his owner, Henry Huggins, in a shopping center parking lot, an ordinary city dog begins a string of bewildering adventures.

When Ralph and his pesky cousins accidentally make a mess at the Mountain View Inn, Ralph decides that he'd better take his motorcycle and leave. He persuade his young pal Ryan to take him to school, where Ralph is an instant hit with Ryan's classmates. But Ralph doesn't like being told what to do. Worse than that, his precious motorcycle gets broken.

Ramona meets lots of interesting people in kindergarten class, like Davy whom she keeps trying to kiss and Susan whose springy curls seem to ask to be pulled.

In his letters to his favorite author, ten-year-old Leigh reveals his problems in coping with his parents' divorce, being the new boy in school, and generally finding his own place in the world.

Beezus Quimby tries very hard to be patient with her little sister, but four-year-old Ramona has the habit of doing the most unpredictable, annoying, embarrassing things in the world.

For the well-meaning Henry Huggins, nothing ever works out quite as planned including getting the bike of his dreams. Luckily his pal Beezus Quimby is there to help! Henry's attempts at raising money for his bike fund keep falling flat. Selling bubble gum on the playground gets him in trouble with his teacher, and then Ribsy's nose for mischief almost ruins Henry s paper route. Even pesky little Ramona Quimby manages to get in the way of Henry's chance...

The happy home life of Socks, the cat, is disrupted by the addition of a new baby to the household.

Follows the adventures of nine-year-old Ramona at home with big sister Beezus and baby sister Roberta and at school, in fourth grade, in Mrs. Meacham's class.